The annual mortality burden, the causes of mortality, and the changes over time are key indicators of population change. In the US, mortality statistics are derived from death certificate data from the National Center for Health Statistics National Vital Statistics System. These data provide both the annual mortality burden in numbers and by cause of death. Herein, we summarize the key findings from the newly released report from the National Center for Health Statistics on the leading causes of death in the US from 2019 to 2023.